Is Riot Vanguard the best anti-cheat software?

Vanguard is really just an anti-cheat system for Riot games in particular, so I wouldn't necessarily say it's the best, and though it is VERY good at what it does, many hackers still make their way into the game and use cheats to unfairly stomp on us. However, Buff shouldn't come up flagged on any anti-cheat system, as Overwolf is widely accepted as a legitimate info display.